دو مقاله درباره پزشکی شخصی در درمان سرطان

نمونه از متن مقاله 

The role of MSCs in tumorigenesis is controversial. There is huge

evidence about a tumor-promoting role of MSCs, opposed by studies

pointing to an anti-tumor effect which is specific to the very early stages

of tumor development. It is in connection with the course of a chronic

inflammatory condition like inflammatory bowel disease (IBD), where

the epithelium becomes inflamed and damaged, leading thus to the

over-expression of transcription factors such as nuclear factor kappa B

(NF-κB), signal transducers and activators of transcription STAT 3 and

STAT6, all of which are potentially tumorigenic [24]. Administration of

MSCs at this very early stage can have a tumor inhibiting effect by

decreasing interleukin IL-6 and phosphoSTAT3 signaling and reducing

DNA damage. After this very early stage, MSCs are recruited to the

tumor by factors such as NF-κB, chemokine receptor type 4 (CXCR4),

stromal cell derived factor (SDF)− 1, monocyte chemotactic protein

(MCP)− 1 and vascular cell adhesion molecule (VCAM)− 1. Such factors,

synergistically promote tumorigenesis via differentiation of

cancer-associated fibroblasts (CAFs), promoting tumor growth, inva-

sion, metastasis and angiogenesis and the dampening of anti-tumor

immunity [24–27].